Time flies, 2023 has passed in the blink of an eye. LuoLab's annual year-end summary meeting was successfully held on February 3rd, 2024, where the laboratory members reviewed their work progress in 2023 and looked forward to the following 2024. First of all, Dr. Zhang made a summary from the spatio-temporal dynamic regulation of RNA modification and metagenomic and element mining, and shared her gains and insights.
On Jan. 14th, 2023, an annual meeting was held to review our work in the last year and to look forward to the future. This time, we were honored to invite Dr. Feng Guihai, Dr. Jia Xiaoyan, Dr. Xu Jin and Dr. Liu Li as guests to attend the meeting. Their insightful comments and generous advice eminently inspired all of us and were greatly appreciated!
From August 8th to 10th, we had our long-awaited 3-day summer trip to Hailing Island, though it was just after the start of autumn in 24 Solar Terms.
Cooperating with Nan Cao, our lab published an article, which entitled “Co-effects of m6A and chromatin accessibility dynamics in the regulation of cardiomyocyte differentiation”, in Epigenetics & Chromatin on August 11th. Xue-Hong Liu is the co-first author. Ze-Hui Ren, Hong-Xuan Chen and Ying Zhang also made great contribution to this work. Congratulations to them!
N6-methyladenosine (m6A) is the most abundant and thoroughly studied RNA modification base in vertebrates. Currently, m6A detection is mainly based on second-generation sequencing methods, which have problems such as false positives, complex operations, and limited to site detection. Gradually, nanopore sequencing technology (Oxford Nanopore Technologies, ONT) has become an ideal alternative method. Although many highly complex and advanced computational tools have been developed to detect and quantify m6A via nanopore sequencing, there is still a lack of research to thoroughly evaluate and compare these tools.
On December 27th, 2022, our lab has established a new method termed MM-seq for genome-wide 6mA mapping, as the paper entitled “High-precision mapping reveals rare N6-deoxyadenosine methylation in the mammalian genome” published in Cell Discovery. Li-Qian Chen and Zhang Zhang are the co-first authors. Hong-Xuan Chen, Jian-Fei Xi, Xue-Hong Liu, Dong-Zhao Ma, Yu-Hao Zhong, Wen Hui Ng and Tao Chen has also made contribution to this work. Congratulations!
On Nov. 25th, 2019, Dr. Chun Wang, from China National Rice Research Insititute, gave a lecture about “The Application of Gene Editing Tools in Plant Breeding”.
We are very excited to having Prof. Chuan He here! He gave a talk on the topic of “Reversible DNA and RNA Methylation in Gene Expression Regulation”.