E-mail: chenhongxuan1997@icloud.com
Mechanism and detection of epigenetic modifications.
Authors from the Luo Lab are marked with ^, first authors marked with #, and corresponding authors marked with *.
Zhang, Y.#^, Zhang, Z. Y.#^, Chen, H. X.#^, Liu, C., Liu, B. D.^, Lan, Y. L.^, Xie, Y. Y.^, Chen, T.^, Chen, S., Feng, G., Zhang, Z.^, Li, W., Cao, N., Wang, X. J., Luo, G. Z.*^(2025). Sequence and parent-of-origin dependent m6A contribute to allele-specific gene expression. The EMBO Journal, Online ahead of print.
PMID:
40461640
DOI:
10.1038/s44318-025-00476-3
Xie, Y. Y.#^, Zhong, Z. D.#^, Chen, H. X.#^, Ren, Z. H.^, Qiu, Y. T.^, Lan, Y. L.^, Wu, F.^, Kong, J. W.^, Luo, R. J.^, Zhang, D., Liu, B. D.^, Shu, Y.^, Yin, F., Wu, J., Li, Z. G., Zhang, Z.*^, Luo, G. Z.*^ (2025). Single-molecule direct RNA sequencing reveals the shaping of epitranscriptome across multiple species. Nature Communications, 16, 5119.
PMID:
40456740
DOI:
10.1038/s41467-025-60447-4
Chai, G. S.#^, Chen, H. X.^, Ma, D. Z.^, Ren, Z. H.^, Liu, X. H.^, Zhang, Z.^, Luo, G. Z.^* (2025). Comprehensive analysis across mammalian tissues and cells decipher the underlying mechanism of m6A specificity. RNA. Online ahead of print.
PMID:
40316420
DOI:
10.1261/rna.080222.124
Xi, J. F.#^, Liu, B. D.#^, Tang, G. R.#^, Ren, Z. H.^, Chen, H. X.^, Lan, Y. L.^, Yin, F., Li, Z., Cheng, W. S., Wang, J., Chen, L., Yuan, S. C., Zhang, Z.^, Luo, G. Z.*^ (2025). m6A modification regulates cell proliferation via reprogramming the balance between glycolysis and pentose phosphate pathway. Communications Biology, 8(1): 496.
PMID:
6
DOI:
10.1038/s42003-025-07937-9
Ge, Y.#, Chen, R.#, Ling, T., Liu, B.^, Huang, J., Cheng, Y., Lin, Y., Chen, H.^, Xie, X., Xia, G., Luo, G.^, Yuan, S.*, Xu, A.*(2024). Elevated WTAP promotes hyperinflammation by increasing m 6 A modification in inflammatory disease models. The Journal of Clinical Investigation, 134(14).
PMID:
39007267
DOI:
10.1172/JCI177932
Luo, R. J.#^, Chen, H. X.^, Kong, J. W.^, Zhang, Z.^, Ayoub, N., Luo, G. Z.*^(2024). Discovery and Accurate Detection of Rare Nucleic Acid Modifications. Israel Journal of Chemistry, 64(5): e202400024.
PMID:
2
DOI:
10.1002/ijch.202400024
Liu, X. H.#^, Liu, Z.#, Ren, Z. H.^, Chen, H. X.^, Zhang, Y.^, Zhang, Z.*^, Cao, N.*, Luo, G. Z.*^(2023). Co-effects of m6A and chromatin accessibility dynamics in the regulation of cardiomyocyte differentiation. Epigenetics & Chromatin, 16(1): 1-13.
PMID:
37568210
DOI:
10.1186/s13072-023-00506-6
Zhong, Z. D.#^, Xie, Y. Y.#^, Chen, H. X.^, Lan, Y. L.^, Liu, X. H.^, Ji, J. Y.^, Wu, F.^, Jin, L., Chen, J., Mak, D. W., Zhang, Z.*^, Luo, G. Z.*^(2023). Systematic comparison of tools used for m6A mapping from nanopore direct RNA sequencing. Nature Communications, 14(1): 1906.
PMID:
37019930
DOI:
10.1038/s41467-023-37596-5
Chen, L. Q.#^, Zhang, Z.#^, Chen, H. X.^, Xi, J. F.^, Liu, X. H.^, Ma, D. Z.^, Zhong, Y. H.^, Ng, W. H.^, Chen, T.^, Mak, D. W., Chen, Q., Chen, Y. Q. and Luo, G. Z.*^(2022). High-precision mapping reveals rare N6-deoxyadenosine methylation in the mammalian genome. Cell Discovery, 8(1), 1-11.
PMID:
36575183
DOI:
10.1038/s41421-022-00484-1
Li, Y.#^, Zhi, S.#, Wu, T.#, Chen, H. X.^, Kang, R., Ma, D. Z.^, Songyang, Z., He, C.*, Liang, P*. and Luo, G. Z.*^ (2022). Systematic identification of CRISPR off-target effects by CROss-seq. Protein & Cell.
PMID:
37084235
DOI:
10.1093/procel/pwac018
Chen, HX^, Zhang, Z^, Ma, DZ^, Chen, LQ^, Luo, GZ^*. Mapping single-nucleotide m6A by m6A-REF-seq[J]. Methods, 2022, 203: 392-398.
PMID:
34174388
DOI:
10.1016/j.ymeth.2021.06.013
Zhang, Z.#^, Chen, T.#^, Chen, H. X.^, Xie, Y. Y.^, Chen, L. Q.^, Zhao, Y. L.^, Liu, B. D.^, Jin, L., Zhang, W., Liu, C., Ma, D. Z.^, Chai, G. S.^, Zhang, Y.^, Zhao, W. S.^, Ng, W. H., Chen, J., Jia, G., Yang, J. and Luo, G. Z.*^ (2021). Systematic calibration of epitranscriptomic maps using a synthetic modification-free RNA library. Nat Methods 18, 1213-1222.
PMID:
34594034
DOI:
10.1038/s41592-021-01280-7