As the semester draws to a close and we step into the new year, the members of LuoLab have once again made remarkable progress and forged valuable experiences in 2024. To review our growth and progress over the past year, LuoLab held an annual report meeting for 2024 on January 21, 2025. The report was organized into sessions according to research themes, with members taking turns to present their progress and achievements on the path of scientific research, sharing their personal growth and their outlook for the future.
Time flies, 2023 has passed in the blink of an eye. LuoLab's annual year-end summary meeting was successfully held on February 3rd, 2024, where the laboratory members reviewed their work progress in 2023 and looked forward to the following 2024. First of all, Dr. Zhang made a summary from the spatio-temporal dynamic regulation of RNA modification and metagenomic and element mining, and shared her gains and insights.
On Jan. 14th, 2023, an annual meeting was held to review our work in the last year and to look forward to the future. This time, we were honored to invite Dr. Feng Guihai, Dr. Jia Xiaoyan, Dr. Xu Jin and Dr. Liu Li as guests to attend the meeting. Their insightful comments and generous advice eminently inspired all of us and were greatly appreciated!
Recently, our lab published a research article titled “m6A modification regulates cell proliferation via reprogramming the balance between glycolysis and pentose phosphate pathway” in Communications Biology. Congratulations to Jian-Fei Xi, Biao-Di Liu, and Guo-Run Tang, who contributed as co-first authors! This work reveals how a chemical modification on RNA—known as m6A—acts as a molecular “brake” to suppress cancer cell proliferation by rewiring energy metabolism. These findings offer novel therapeutic strategies for precision oncology.
Cooperating with Nan Cao, our lab published an article, which entitled “Co-effects of m6A and chromatin accessibility dynamics in the regulation of cardiomyocyte differentiation”, in Epigenetics & Chromatin on August 11th. Xue-Hong Liu is the co-first author. Ze-Hui Ren, Hong-Xuan Chen and Ying Zhang also made great contribution to this work. Congratulations to them!
N6-methyladenosine (m6A) is the most abundant and thoroughly studied RNA modification base in vertebrates. Currently, m6A detection is mainly based on second-generation sequencing methods, which have problems such as false positives, complex operations, and limited to site detection. Gradually, nanopore sequencing technology (Oxford Nanopore Technologies, ONT) has become an ideal alternative method. Although many highly complex and advanced computational tools have been developed to detect and quantify m6A via nanopore sequencing, there is still a lack of research to thoroughly evaluate and compare these tools.
On Nov. 25th, 2019, Dr. Chun Wang, from China National Rice Research Insititute, gave a lecture about “The Application of Gene Editing Tools in Plant Breeding”.
We are very excited to having Prof. Chuan He here! He gave a talk on the topic of “Reversible DNA and RNA Methylation in Gene Expression Regulation”.