Guoshi Chai

PhD Student
Bioinformatics, Sun Yat-sen University
M.S., Biophysics, University of Electronic Science and Technology of China
B.S., Bioinformatics, Shanxi Agricultural University
chai@immunet.cn

E-mail: chaigsh@mail2.sysu.edu.cn

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Research and Scholarly Interests

MeRIP-seq data analysis and off target analysis of CRISPR -associated nucleases.

Publications

Authors from the Luo Lab are marked with ^, first authors marked with #, and corresponding authors marked with *.

Chai, G. S.#^, Chen, H. X.^, Ma, D. Z.^, Ren, Z. H.^, Liu, X. H.^, Zhang, Z.^, Luo, G. Z.^* (2025). Comprehensive analysis across mammalian tissues and cells decipher the underlying mechanism of m6A specificity. RNA. Online ahead of print.
PMID: 40316420 DOI: 10.1261/rna.080222.124

Zhang, Z.#^, Chen, T.#^, Chen, H. X.^, Xie, Y. Y.^, Chen, L. Q.^, Zhao, Y. L.^, Liu, B. D.^, Jin, L., Zhang, W., Liu, C., Ma, D. Z.^, Chai, G. S.^, Zhang, Y.^, Zhao, W. S.^, Ng, W. H., Chen, J., Jia, G., Yang, J. and Luo, G. Z.*^ (2021). Systematic calibration of epitranscriptomic maps using a synthetic modification-free RNA library. Nat Methods 18, 1213-1222.
PMID: 34594034 DOI: 10.1038/s41592-021-01280-7

Chen, W.#, Ren, Z.H.#^, Tang, N., Chai, G.^, Zhang, H., Zhang, Y., Ma, J., Wu, Z., Shen, X., Huang, X., Luo, G.Z.*^, Ji Q.J.* (2021). Targeted genetic screening in bacteria with a Cas12k-guided transposase. Cell Reports, 36, 109635.
PMID: 34469724 DOI: 10.1016/j.celrep.2021.109635

Chen X#, Zhao Q#, Zhao YL#, Chai GS, Cheng W, Zhao Z, Wang J*, Luo GZ*, Cao N*. Targeted RNA N6-Methyladenosine Demethylation Controls Cell Fate Transition in Human Pluripotent Stem Cells. Advanced Science (Weinh). 2021 Jun;8(11):e2003902
PMID: 34105279 DOI: 10.1002/advs.202003902

Lin X#, Chai G#^, Wu Y#, Li J, Chen F, Liu J, Luo G^, Tauler J, Du J, Lin S, He C, Wang H*. RNA m6A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail. Nature Communications. 10: 2065 (2019)
PMID: 31061416 DOI: 10.1038/s41467-019-09865-9